Empowering Breast Cancer Care Through Cannabis Education

Dear Green Nurse,
I recently had the pleasure of watching your podcast with Vera, The Cancer Goddess, and also attended your live presentation on Cannabis and Breast Cancer for the Breast Cancer Goddess Support Group on Vera’s platform supporting her non profit. I found your insights incredibly valuable and was hoping you could shed some light on a topic I’ve been curious about.

I’ve heard there’s some controversy surrounding the use of cannabis products for hormonally driven cancers and the role of cannabinoids during immunotherapy. Could you provide some insight into this topic? Additionally, I’d love to know how I can begin incorporating cannabinoids into my routine for health, wellness, and potentially for cancer prevention now that I am in remission. Your expertise would be greatly appreciated. Thank you!

Sincerely,
Recently in Remission

Dear Recently in Remission ️,
Congratulations on achieving remission! I’m glad you reached out with your questions and thank you for your kind words and for taking the time to engage with the podcast and presentation—it truly means so much to know that the information resonated with you. It’s an honor to walk alongside you on your journey of healing, self-discovery, and empowerment. Your thoughtful and important questions deserve clarity, and I’m more than happy to provide it.

A breast cancer diagnosis can feel overwhelming, bringing with it a cascade of complex decisions, emotional challenges, and the search for effective, compassionate care. More and more, individuals are exploring integrative and holistic approaches to complement traditional cancer treatments, with cannabis emerging as a valuable ally in managing symptoms and supporting the healing process.

The Cannabis & Breast Cancer Resource Guide was created by us to bridge the gap between curiosity and understanding. This guide provides evidence-based insights, therapeutic protocols, and practical resources designed to empower patients, caregivers, and healthcare professionals alike. By drawing on the latest research, expert perspectives, and real-world applications, it sheds light on how cannabinoids may support different breast cancer subtypes, alleviate treatment-related side effects, and potentially influence disease progression.

Whether you are newly diagnosed, undergoing active treatment, or navigating survivorship, this guide is tailored to meet you exactly where you are. It offers not only cutting-edge science but also compassionate support. Let it serve as a source of hope and informed decision-making on your path to healing.

For your cannabis and hemp cancer care needs, we’re here to support you every step of the way. Whether you prefer to reach out by phone through our free nurse line at 970-404-HOPE (4673) or by email at [email protected], our team is ready to guide you in selecting the products that best suit your unique needs and your personal journey. Simply complete the free intake form under the “Services” tab, and we’ll provide you with a personalized care plan delivered straight to your inbox.

With you on the journey,
Nurse Sherri – The Green Nurse

Breast Cancer and Cannabinoids – Resource and Guide

Women Are Using Cannabinoids for Breast Cancer – As more individuals turn to integrative approaches to manage cancer-related symptoms, the use of cannabis among breast cancer patients has become an increasingly important area of study. In fact, a recent survey published in the journal Cancer revealed that a significant portion of breast cancer patients are using cannabis during various stages of their treatment—including chemotherapy, radiation, and surgery—not only for symptom relief but with the belief that it may help treat the cancer itself (Weaver et al., 2022).

This survey reported that 42% of respondents reported cannabis use, primarily to manage symptoms like pain, insomnia, anxiety, stress, and nausea. Interestingly, nearly half (49%) believed cannabis could have antineoplastic benefits, despite limited clinical evidence. However, only 39% had discussed their cannabis use with their oncologists, highlighting a concerning communication gap between patients and providers (Weaver et al., 2022). As cannabis legalization expands and public interest grows, it’s increasingly critical for healthcare professionals to initiate open conversations about cannabis use to ensure safety, efficacy, and coordinated care. This is an abbreviated guide and resource on cannabinoids for breast cancer care and treatment.

This image comes from Cannakeys, our go-to resource for cutting-edge cannabinoid research. Their in-depth insights and comprehensive studies help us educate others on how cannabinoids can be used to manage various conditions and symptoms, while also promoting the care and health of the endocannabinoid system.

Research and Preclinical Trials from the Cannakeys research dashboard show complex interactions of components of the Endocannabinoid System and their consequent direct ability to therapeutically influence breast cancer through several different mechanisms, including:

• Blocking cancer cell cycle progression and growth
• Inducing apoptosis (cancer cell death)
• Inhibiting cancer cell migration and proliferation
• Modulating genetic expression to stop the spread
• Inhibiting cancer cell blood supplies (angiogenesis) to starve cancer cells

Research has shown that breast cancer is highly associated with ID-1, a gene linked to increased tumor growth, and that CBD and CBDA downregulates ID-1, suggesting potential antineoplastic activity against breast cancer (Cannabis Cancer Connection, 2023, McAllister et al., 2007)

Triple Negative Breast Cancer (TNBC) – Triple-negative breast cancer (TNBC) accounts for approximately 10-20% of all breast cancer cases. Known for its complexity and aggressive behavior, TNBC lacks estrogen and progesterone receptors, and when amplified by HER2, it becomes even more challenging to treat due to its highly metastatic nature. However, there is promising news—TNBC expresses cannabinoid receptors, particularly CB2 more than CB1. The high expression of CB2 receptors presents a unique opportunity for cannabinoids to target and potentially eliminate cancer cells, offering new avenues for treatment. (Cannabis Cancer Connection, 2023).

The Protocol treating Triple Negative Breast Cancer with cannabinoids is as follows:

• CBD – 100-300mg a day of Full Spectrum CBD
• CBG – 100-300mg a day of Full Spectrum CBG
• THC – Titrating up to the highest possible amount you could tolerate of the Full Extract High Dose THC Oil (RSO Oil) which is different for everyone. (Cannabis Cancer Connection, 2023).

HER2-Positive Breast Cancer – Approximately 15-20% of all breast cancers are HER2-positive, meaning they are driven by the HER2 gene, which makes them more aggressive in nature. (Cannabis Cancer Connection, 2023).

The Protocol treating HER2-Positive Breast Cancer with cannabinoids is as follows:

• CBD – 100-300mg a day of Full Spectrum CBD
• CBG – 100-200mg a day of Full Spectrum CBG
• CBDA – 50-150mg a day of Non-Decarboxylated Raw Cannabinoids in form of CBDA
• THC – Titrating up to the highest possible amount you could tolerate of the Full Extract High Dose THC Oil (RSO Oil) which is different for everyone. (Cannabis Cancer Connection, 2023).

Dr. Christina Sanchez’s Research and Findings on CBD and THC (Complutense University of Madrid)
These studies suggest that while isolated cannabinoids offer promise, whole-plant cannabis extracts may provide more robust therapeutic outcomes in the treatment of HER2-positive breast cancer.

• Dr. Cristina Sánchez has contributed significantly to the growing body of research exploring the antitumor properties of cannabinoids in HER2-positive breast cancer. In a 2010 study, Sánchez and colleagues demonstrated that cannabinoids, particularly THC and CB2-selective agonists such as JWH-133, effectively inhibited HER2-positive breast cancer progression in preclinical models. The study showed that these compounds suppressed cancer cell proliferation, induced apoptosis, and reduced tumor angiogenesis by interacting with CB2 receptors (Caffarel et al., 2010).
• Expanding upon these findings, a 2018 study led by Sánchez compared the anticancer efficacy of pure THC to that of a botanical drug preparation (BDP) high in THC, commonly referred to as Full Extract Cannabis Oil (FECO) or Rick Simpson Oil (RSO). The researchers found that the whole-plant extract was significantly more effective than isolated THC in reducing tumor growth in HER2-positive breast cancer models. This enhanced efficacy was attributed to the “entourage effect,” where multiple cannabis compounds act synergistically to increase antitumor activity (Blasco-Benito et al., 2018)

Hormone Positive (Estrogen & Progesterone) Breast Cancer – Hormone receptor status is a key factor in breast cancer classification and treatment planning. Approximately 70% to 80% of all breast cancers are estrogen receptor-positive (ER+), making this the most common subtype. Among these, around 65% are also progesterone receptor-positive (PR+), indicating a dual hormone-responsive tumor profile (American Cancer Society, 2024). In contrast, tumors that are estrogen receptor-negative but progesterone receptor-positive (ER−/PR+) are extremely rare, comprising only about 1.6% of all breast cancer diagnoses (Howlader et al., 2014). Understanding these distinctions is crucial, as hormone receptor status directly influences therapeutic strategies and prognosis.

• 70 -80% of all breast cancers are estrogen positive.
• 65% of all estrogen positive are also progesterone positive
• 1.6% of all cancers are progesterone positive and estrogen negative, making it least common

Estrogen Positive Cancer Studies and Varying Results

• Synthetic tetrahydrocannabinol (THC) has been shown to be ineffective in inducing cell death in estrogen receptor-positive breast cancer cells that lack cannabinoid receptors CB1 and CB2. In the absence of these receptors, the mechanism by which THC typically exerts antineoplastic effects is compromised (Blasco-Benito et al., 2018).
• Furthermore, preclinical studies in murine models demonstrated that the administration of high doses of synthetic THC oil was associated with adverse outcomes, including increased tumor growth, metastasis, and immunosuppression. These effects indicate that excessive concentrations of isolated synthetic THC may not only be ineffective but potentially harmful in oncologic settings (Blasco-Benito et al., 2018).
• In contrast, Full Extract Cannabis Oil (FECO)—which contains a broad spectrum of cannabinoids, terpenes, and other phytochemicals—has shown a more favorable impact on tumor suppression. Estrogen and progesterone receptor-positive breast cancer in mice responded more positively to FECO treatment than to synthetic THC alone, with notable reductions in tumor growth observed (Blasco-Benito et al., 2018).
• Complementary research by Dr. Cristina Sánchez highlights the therapeutic potential of combining THC FECO with standard hormone therapy. In preliminary preclinical findings, the combination of Tamoxifen and FECO resulted in a significant decrease in tumor growth, suggesting a synergistic effect between whole-plant cannabis extracts and conventional anti-estrogenic agents (Sánchez, 2017).
• In the Cannabis Cancer Connection book, Dr Goldstrich states, “I could not conclude the results of this study proved THC would stimulate the growth of estrogen positive breast cancer treated with reasonable and tolerable doses of THC found in FECO taken by human patients. There is no clinical evidence that THC or any other cannabinoid will make any type of breast cancer better or worse in humans.” (Cannabis Cancer Connection, 2023).

THC and Estrogen Receptor – Estrogen exerts its effects by binding to two primary receptors: estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ). Activation of ERα is associated with the proliferation of certain cancer cells, whereas activation of ERβ has been shown to inhibit cancer cell growth. A 2013 study by Takeda et al. demonstrated that Δ9-tetrahydrocannabinol (THC) exhibits anti-estrogenic activity by downregulating ERα and upregulating ERβ, thereby disrupting estrogen signaling pathways. This modulation suggests that THC may impede cancer progression by altering the balance between these receptors. (Takeda et al., 2013).

Tamoxifen – THC & CBD

• Tamoxifen functions much like a “broken key” in a lock—it binds to the estrogen receptor (ER), preventing estrogen from activating the receptor and thus inhibiting the proliferation of estrogen receptor-positive breast cancer cells (Jordan, 2003). Although tamoxifen is primarily indicated for estrogen receptor-positive breast cancer, it has demonstrated some antineoplastic effects in receptor-negative cases through mechanisms not directly tied to estrogen inhibition (Early Breast Cancer Trialists’ Collaborative Group [EBCTCG], 2011).
• Cannabinoids such as THC and CBD may enhance the therapeutic impact of tamoxifen by influencing its metabolism. Tamoxifen is a prodrug that must be metabolized by cytochrome P450 enzymes—primarily CYP2D6—into its active form, endoxifen, which exerts the actual anti-estrogenic effect (Zendulka et al., 2023). Some studies suggest that cannabinoids may potentiate tamoxifen’s cytotoxic effects against cancer cells, potentially improving its efficacy as an antineoplastic agent (Blasco-Benito et al., 2020).
• However, there is a dual concern regarding the concurrent use of cannabinoids and tamoxifen. Both THC and CBD have been shown to inhibit CYP2D6, which could impair the conversion of tamoxifen into endoxifen, potentially diminishing its estrogen-blocking capability (Zendulka et al., 2023). This means that while cannabinoids might enhance tamoxifen’s ability to kill cancer cells through other mechanisms, they could also reduce its effectiveness in blocking estrogen.
• For postmenopausal women, the American Cancer Society recommends considering aromatase inhibitors as an alternative to tamoxifen. These agents work by lowering estrogen levels systemically, thereby reducing the growth stimulus for hormone receptor-positive breast cancers (American Cancer Society, 2021).

CBD & Estrogen Positive Breast Cancer – Five Studies

1. Egyptian Researchers found that CBD induced apoptosis (programmed cell death) through several mechanisms. (Sultan et al., 2018)
2. Harvard Medical School Researchers published a study showing, “CBD inhibited the survival of both estrogen receptor-positive and estrogen receptor-negative breast cancer cell line and induced apoptosis in a concentration-dependent manner.” (Shrivastava et al., 2011)
3. In 2019, researchers from Austria and Slovakia published a comprehensive review examining cannabinoids with antineoplastic properties against breast cancer cells, including the effects of CBD on estrogen-positive breast cancer. They concluded that, while cannabinoids are primarily used to alleviate symptoms such as nausea, anorexia, and neuropathic pain, “these compounds may also play a role in slowing tumor progression during earlier stages of the disease” (Kisková et al., 2019).
4. Italian researchers have confirmed that THC effectively kills MCF-7 estrogen-positive breast cancer cells. Furthermore, their findings revealed that CBD and CBG are even more potent as antineoplastic agents, surpassing the efficacy of THC (Ligresti et al., 2006).
5. Portuguese researchers confirmed that CBD was the most crucial cannabinoid for the treatment of estrogen-positive breast cancer and that THC plays a secondary role (Amaral et al., 2021).

The Protocol treating Estrogen Positive Breast Cancer with cannabinoids is as follows:

• CBD – 300-400 mg a day of Full Spectrum CBD
• CBG – 100-150mg a day of Full Spectrum CBG
• CBDA – 100 -150mg a day of Non-Decarboxylated Raw Cannabinoids in form of CBDA
• THCA – 100-150 mg a day of Non-Decarboxylated Raw Cannabinoids in form of THCA
• THC – 25-40mg a day (Cannabis Cancer Connection, 2023).

Dr. Joe Goldstrich writes “After reviewing all the research I have concluded that the assertion THC stimulates the growth of human estrogen-positive breast cancer is not supported by published, peer reviewed scientific literature. However, CBD appears to be the most potent cannabinoid above all others for breast cancer” (Cannabis Cancer Connection, 2023).

Immunotherapy – Immunotherapy is used to stimulate the immune system to attack cancer. High doses of cannabinoids such as THC and CBD may impair immune function and reduce the effectiveness of immunotherapy by interfering with the generation of necessary antibodies. While low doses may help manage symptoms, higher doses should be avoided during immunotherapy to prevent compromising treatment outcomes (Bar-Sela et al., 2020). We suggest and recommend that patients use minimal cannabinoids around immunotherapy days only to relieve distressing symptoms and to let the immunotherapy do its job to generate the necessary antibodies needed for treatment. For example, 3 days prior – fast from cannabinoids, 3 days after – fast from cannabinoids. If you are relying on cannabinoids as your medicine to treat symptoms, consider reducing both THC and CBD to the minimum effective dose needed to alleviate symptoms.

Looking Ahead: Cannabis in Cancer Aftercare – At present, there is a notable lack of formal research or clinical guidelines outlining what a cannabis-based aftercare or maintenance plan should look like for individuals who have used cannabinoids during cancer treatment. While many patients continue to use cannabis after active therapy for symptom management such as pain, insomnia, anxiety, or nausea—there is insufficient evidence to support its use in preventing recurrence or sustaining remission (American Cancer Society, 2021; Pergam et al., 2024).

One recent study from Fred Hutch Cancer Center found that over 40% of cancer patients use cannabis post-diagnosis, yet most do so without clinical oversight, highlighting the urgent need for evidence-based guidance (Pergam et al., 2024). Until more rigorous research emerges, patients are encouraged to work closely with oncology and integrative care providers when considering cannabis in survivorship care planning. Personalized, informed decisions remain essential for balancing potential benefits with safety and long-term wellness.

Holistic Caring & The Green Nurse and Bloom Hemp CBD Consumers

Many patients and consumers turn to Bloom Hemp CBD products as part of their pre- and post-cancer care, integrating them into their treatment plans for added support. Bloom Hemp provides personalized care plans and access to a free nurse hotline, offering vital assistance throughout the healing process. To further enhance cannabinoid-based care, Holistic Caring and The Green Nurse offer education, coaching, and consulting services, along with coaching packages designed to help patients optimize their therapeutic approach and navigate dispensary purchases for THC products. Many individuals start their journey with Bloom Hemp because its gentle, healing properties complement THC products from dispensaries seamlessly, creating a balanced and effective path to wellness.

• Products During Cancer Care from Bloom Hemp – What patients are using
  • Bloom Hemp Essentials Digestive Tincture (CBD, CBG, 0.3% THC)
  • Bloom Hemp Advanced Trilogy Tincture (CBD, CBG, CBN, 0.3% THC)
  • Bloom Hemp Advanced Immunity Softgels (CBD, CBG, CBDA, CBGA)
  • Bloom Hemp Full Spectrum Soft Gels (CBD, 0.3% THC)
  • Bloom Hemp Advanced T65 Gummies (CBD, CBG, CBN, THC)
  • Bloom Hemp Topicals (CBD, CBG, CBN)
  • Bloom Hemp Isolates to boost the THC RSO Oil from dispensary or create your own blends.

• Products For After Cancer Care from Bloom Hemp – If you’re new to working with us, explore the different products below and reach out to us to receive a free customized care plan delivered straight to your inbox with the best products suited for you and your needs.
  • Bloom Hemp Tinctures (CBD, CBG, CBN, THCV, 0.3% THC)
  • Bloom Hemp Topicals (CBD, CBG, CBN)
  • Bloom Hemp Gummies (CBG, CBG, CBN, THC, THCV)
  • Bloom Hemp Softgels (CBD, CBG, CBDA, CBGA, 0.3% THC)
  • Bloom Hemp Isolates to create your own blends with THC RSO (CBD, CBG, CBN)

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Bloom Hemp CBD Supports and Nourishes the Endocannabinoid System

Nurturing the Endocannabinoid System begins with four essential pillars: Nutrition, Movement, Connection, and Rest. These foundational elements are integral to human growth, healing, and well-being, representing the most powerful form of natural medicine available.

Rest – The Foundation of Recovery. Quality sleep is vital for cellular repair, mental clarity, and emotional stability. Without adequate rest, the body struggles to manage inflammation, stress, and overall health. Bloom Hemp CBD offers a range of products designed to promote relaxation, support deep REM cycles, and enhance restorative sleep, helping to regulate the body’s natural circadian rhythm.

Nutrition – Fueling the Body & Mind. A balanced diet is essential for fueling metabolism, boosting immunity, and enhancing brain function. The endocannabinoid system (ECS) plays a key role in regulating appetite, digestion, and gut health, ensuring efficient nutrient absorption. Nourishing the body with whole, nutrient-rich foods supports cellular function, fortifies the immune system, and promotes mental clarity and emotional well-being. Hemp-derived nutrients further enhance gut health, provide essential fatty acids, and support both brain and immune function, making them a powerful addition to a healthy lifestyle.

Movement – Keeping the Body in Motion. Regular physical activity boosts circulation, enhances mobility, and sharpens mental clarity, all while alleviating stress and reducing pain. The endocannabinoid system (ECS) plays a crucial role in supporting muscle function, promoting pain relief, and aiding recovery. By staying active, you not only strengthen your body and mind but also build resilience and enhance overall longevity. Full Spectrum CBD topicals and tinctures support muscle recovery, joint health, pain relief by reducing inflammation and stiffness, aiding an active lifestyle by helping you to become more active.

Connection – Healing Through Community & Relationships. Strong social bonds and meaningful emotional connections are essential for reducing stress, supporting mental health, and fostering resilience. The endocannabinoid system (ECS), a key regulator of mood, memory, and emotional well-being, highlights the vital role connection plays in overall health. Building relationships and cultivating a sense of community not only promote emotional stability but also help ease anxiety and enhance purpose and fulfillment.

At Bloom Hemp, we understand the power of connection. We are dedicated to supporting your journey toward lasting health and wellness. Whether you’re just starting out or looking to deepen your wellness routine, our range of carefully crafted products is here to help you achieve your unique goals. Our Free Nurse Line connects you with compassionate nurses and pharmacists ready to answer your questions—call us anytime at 970-404-HOPE (4673). Free emailed care plans are just a click away into your inbox after filling out an intake form on the Bloom Hemp Service Link. Additionally, the Holistic Caring Network offers a global community that unites patients, providers, and individuals in a supportive space. Join us for free online events and a complimentary plant medicine support group, where shared learning and connection thrive. Your journey to better health starts with Bloom Hemp CBD supported by Holistic Caring & The Green Nurse.